Pushing the Boundaries of Science: Our 2025 Scientific Publication Report
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Pushing the Boundaries of Science
Medicine has no concept of ‘standing still,’ because diseases never stop: they evolve and change. Our duty as physicians is not only to use existing knowledge but also to generate new knowledge.
For our team, 2025 marked a peak in academic productivity. We contributed across a broad spectrum, from real-world data on prognostic tests in breast cancer to the genetic codes of HPV-related cancers, from AI-assisted analyses in rectal cancer to the boundaries of liquid biopsy. These studies are more than academic texts: each is a step toward better, more personalized, and more effective treatment for our patients.
Breast Cancer and Precision Medicine
Our studies seeking real-world answers to ‘which treatment, for whom, and how much?’ in breast cancer.
- Prognostic Value of Oncotype DX Recurrence Score in Early-Stage Hormone Receptor-Positive, HER2-Negative Breast Cancer: A Real-World Experience Turkish Journal of Clinics and Laboratory, 2025 (Online First)
- Survival of Patients with Breast Cancer Who Underwent Oncotype DX Recurrence Score Testing: Long‐Term Survival Update World Journal of Surgery, 2025
- Examining the Correlation and Concordance Between Ki-67 Expression and Oncotype DX Recurrence Score Breast, 2025
- Predictors of Pathologic Complete Response and Its Prognostic Value in Early Breast Cancer Current Oncology, 2025
HPV and Viral Oncology
Our pioneering research examines the virus–cancer relationship at the molecular level to advance future cancer vaccines and treatments.
- Mitochondrial DNA Alterations in HPV-Related Cancers: Emerging Insights and Future Directions Viruses, 2025
- Clinical and Therapeutic Applications of Exosomes in HPV-Associated Malignancies: Biomarkers, Liquid Biopsy, and Emerging Therapies Cancers, 2025
- Genome Editing Against HPV-Driven Cancers: From Bench to Clinic Acta Microbiologica Hellenica, 2025
- Exosomes in HPV-Associated Cancers: From Biomarkers to Engineered Therapeutics Cancers (Basel), 2025
- Molecular Insights into HPV-Driven Head and Neck Cancers: From Viral Oncoproteins to Precision Therapeutics Viruses, 2025
- Emerging Therapeutic Strategies for HPV-Related Cancers: From Gene Editing to Precision Oncology Current Issues in Molecular Biology, 2025
- Papillomavirus-Induced Oncogenesis: Bridging Molecular Mechanisms, Diagnostics, and Global Prevention Strategies Viruses, 2025
Genetics and Liquid Biopsy
Groundbreaking work on mapping cancer genetics and diagnosing disease through blood.
- Analytical Validation of a 1021-Gene NGS Panel for Comprehensive Tumor Profiling in FFPE and Liquid Biopsy Samples Journal of Clinical Oncology, 2025
- Comprehensive Evaluation of a 1021-Gene Panel in FFPE and Liquid Biopsy for Analytical and Clinical Use International Journal of Molecular Sciences, 2025
- Multilocus inherited neoplasia allele syndrome (MINAS) in a Turkish cohort Frontiers in Pharmacology, 2025
- High-Throughput Drug Testing and Synergy Evaluation in Patient-Derived Tumor Organoids Methods in Molecular Biology, 2025
Therapeutic Resistance and Radiotherapy
Discovering mechanisms to overcome treatment resistance and improve outcomes in solid tumors.
- Solid Tümörlerde Radyoterapi Direncinin Epigenetik Olarak Hedeflenmesi: Mekanizmalar ve Terapötik Yaklaşımlar Türkiye Klinikleri Radyasyon Onkolojisi Özel Sayısı, 2025
Artificial Intelligence and Predictive Models
Computational oncology research integrating tomorrow’s technologies into today’s treatment.
- Predicting Drug Sensitivity of Cancer Cell Lines to BET Inhibitor OTX015 Using Machine Learning Approaches Preprints, 2025
- Predictive value of tumor marker index for pathological complete response in locally advanced rectal cancer World Journal of Surgical Oncology, 2025
Academic Leadership: Special Issue Editorships
To guide scientific communication and shape global oncology discussions, we have undertaken ‘Guest Editor’ roles in high-impact international journals. In 2025, we managed three major collections spanning viral oncology and precision medicine.
A special issue addressing the cancer-related role of the HPV family, with more than 100 types, its molecular mechanisms, diagnostic tools, and new vaccine strategies globally. This collection contributed 12 comprehensive articles to the literature.
A comprehensive clinical collection examining the molecular foundations, biomarkers, and immunotherapy potential of major cancer-causing infectious agents—not only HPV but also EBV, Hepatitis B/C, KSHV, HTLV-1, and H. pylori.
A research topic combining patient-derived organoids, multiomics profiling, and liquid biopsy to shape the future of ‘personalized cancer treatment’ through studies of tumor heterogeneity and drug resistance.
Published Books
Papillomavirus-Induced Oncogenesis: Current Insights
Publisher: MDPI, 2025
An international reference work addressing the molecular foundations and current treatment strategies of HPV-related cancers worldwide.
Kalıtsal Kanserler Kitabı
Scope: National
The first national reference work in Türkiye to address hereditary cancer syndromes through an interdisciplinary approach.
Innovation: From Theory to Practice
We are active with two ventures combining technology and medicine to turn academic knowledge into bedside benefit: CheckTheLife and CRISERNA.
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Knowledge Multiplies When Shared and Deepens When Created.
This list is more than a record of one year: it reflects our determination in the fight against cancer. Our greatest motivation is knowing that every piece of knowledge generated in 2025 across this broad spectrum—from laboratory to clinic, editorial desk to entrepreneurial ecosystem—may one day touch a patient’s life.
I thank all my teammates, assistants, and scientific partners who contributed. We will continue working toward more in 2026.