Siltuximab
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Approved by the FDA on 23 April 2014, Sylvant is used for multicentric Castleman Disease without human immunodeficiency virus HIV or herpesvirus HHV -type 8-. Castleman Disease is excessive lymph node growth caused by abnormal increases in B lymphocytes and plasma cells, blood cells produced in lymphoid tissues.
Siltuximab blocks IL-6, a molecule involved in producing these cells. Its most common side effects are itching, weight gain, rash, excessive urea production and upper respiratory infections.
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