Tissue Changes Caused by Obesity May Increase Breast Cancer Risk

Obesity is one of the greatest problems of our age. Millions struggle with excess weight resulting from unhealthy eating and irregular lifestyles. Learning proper nutrition from childhood and living actively will protect us from dozens of life-threatening diseases, particularly cancer. In many articles, we have shared guidance and tips with you, our valued followers, on proper eating and adopting a lifestyle for healthy living.

A study published in Science Translational Medicine presented a newly discovered mechanism showing how obesity promotes cancer. It examined obesity's effect on connective tissue called the matrix, which fills spaces between cells. The study found that obesity increases stiffness and changes the framework of intercellular tissue.

The research examined the relationship of obesity and intercellular material with cancer developing in the breast, one of our organs richest in fat tissue. Examination of obese mice's fat showed increased numbers of cells called myofibroblasts and greater stiffness in the matrix filling spaces between cells. Myofibroblasts possess characteristics of both muscle and connective-tissue cells and actively participate in wound healing.

The same stiffening of intercellular connective tissue was identified in fat from obese breast cancer patients. This suggested that obesity-driven stiffness and structural changes are among factors leading to breast tumor formation. In obese mice losing weight through calorie restriction, the fat tissue framework returned to normal. These structural changes, whose role in cancer formation was revealed, have become potential targets for future cancer treatments.

Dear friends, we once again see that obesity can trigger cancer and many life-threatening diseases. However, medical advances and research can now eliminate most obesity problems. Eat properly, seeking an expert dietitian's help if needed, and make exercise part of your life.