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Prof. Dr. Mustafa Özdoğan · Medical Oncologist

Alexandria's Last Surgeon: Paul of Aegina and the Rule of Fire

Alexandria's Last Surgeon: Paul of Aegina and the Rule of Fire
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Day 26 (Cancer History in 365 Days Series)

The 7th century AD. As Alexandria’s library doors closed, its last great surgeon explained more clearly than ever why cancer was called a crab, turning to fire—cauterization—where the scalpel was insufficient.

History's pages turn… The year is AD 640. Alexandria, the ancient world's scientific capital, is about to be conquered by Islamic armies. Amid chaos, a surgeon continues writing at his desk: Paul of Aegina (AD 625-690).

He marked the end of one era and the beginning of another: Greek medicine's last great representative and Islamic medicine's first great teacher. His Epitome Medicae (Medical Compendium) would guide surgeons for centuries, establishing early systematic rules that shaped cancer surgery.

1. The Crab's Anatomy: Unlocking Karkinos

Physicians had called cancer a crab for centuries, but Paul best explained why, transforming the metaphor into an anatomy lesson.

"Vessels around the tumor enlarge and become engorged. They spread radially like legs extending from a crab’s body—the tumor."

ADHERENCE As a crab clings to rock, a tumor adheres to tissue.
MOVEMENT A crab moves sideways and stealthily; cancer also advances through hidden paths.
PAIN The sudden sharp pain of a crab's claw resembles cancer's gnawing pain.

2. The Surgeon's Dilemma: To Cut or Not to Cut?

Paul was skilled but recognized his limits. He did not operate on every tumor. His decision process anticipated modern operability criteria.

SITUATION 1: ULCERATED CANCER
If the tumor has broken through skin and ulcerated, DO NOT TOUCH. Surgery hastens death.
SITUATION 2: DEEP AND ADHERENT
If fixed to the chest wall, the tumor has deep roots. DO NOT TAKE THE RISK.
SITUATION 3: SUPERFICIAL AND MOBILE
If localized, mobile, and not yet spread, THERE IS A CHANCE. Perform mastectomy.

3. Sealing With Fire: The Art of Cauterization

Paul's greatest surgical innovation combined the blade—cold steel—with fire—hot iron. Stopping bleeding was nearly impossible then; he solved this radically.

TECHNIQUE: CUT & BURN

1. Hemostasis (Bleeding Control):
Each severed vessel is sealed by cauterization with red-hot iron, preventing hemorrhagic shock.

2. Drying the Roots (Oncological Clearance):
Paul believed invisible malignant remnants—melancholic roots—remained after tumor removal. He therefore cauterized the entire tumor bed, resembling a primitive form of modern radiotherapy: Clean With Fire Where the Blade Cannot Reach.

DROZDOGAN ACADEMY COMMENTARY

The Torch of Knowledge Passes From Hand to Hand…

Paul of Aegina was one of medical history's great transmitters, bridging Alexandria's accumulated knowledge to the Islamic Golden Age. His techniques were later developed by the Islamic world's greatest surgeon, Abu al-Qasim al-Zahrawi (Albucasis) , then returned to Europe to form a basis for modern surgery.

Paul teaches that science belongs to humanity, not individual nations or religions. As one civilization fades, another takes up the torch, and its flame never dies.

Sources Consulted

  • Karamanou M, et al. "Oncology in the Byzantine Era." JBUON.
  • Gurunluoglu R, et al. "Paul of Aegina: Landmarks in Surgical Progress." World Journal of Surgery.
  • Hajdu SI. "A Note from History: Landmarks in History of Cancer." Cancer.
  • "Paul of Aegina." Wikipedia.
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