Our 2025 Scientific Publications Overview – Advancing the Frontiers of Science
In the world of medicine, there is no such thing as "standing still"; diseases evolve, change, and adapt. Our duty as physicians is not only to apply existing knowledge but also to generate new knowledge.
2025 has been a year of peak academic productivity for our team. From real-world data on prognostic tests in breast cancer to deciphering the genetic codes of HPV-driven cancers; from AI-assisted analyses in rectal cancer to pushing the frontiers of liquid biopsy, we have contributed to science across a broad spectrum. These works are not merely academic texts; each is a step forward in offering better, more personalized, and effective treatments to our patients.
Breast Cancer & Precision Medicine
Seeking answers to "who, which treatment, and how much?" in breast cancer with real-world data.
- Prognostic Value of Oncotype DX Recurrence Score in Early-Stage Hormone Receptor-Positive, HER2-Negative Breast Cancer: A Real-World Experience Turkish Journal of Clinics and Laboratory, 2025 (Online First)
- Survival of Patients with Breast Cancer Who Underwent Oncotype DX Recurrence Score Testing: Long‐Term Survival Update World Journal of Surgery, 2025
- Examining the Correlation and Concordance Between Ki-67 Expression and Oncotype DX Recurrence Score Breast, 2025
- Predictors of Pathologic Complete Response and Its Prognostic Value in Early Breast Cancer Current Oncology, 2025
HPV & Viral Oncology
Pioneering research examining the molecular link between viruses and cancer for future vaccines and therapies.
- Mitochondrial DNA Alterations in HPV-Related Cancers: Emerging Insights and Future Directions Viruses, 2025
- Clinical and Therapeutic Applications of Exosomes in HPV-Associated Malignancies: Biomarkers, Liquid Biopsy, and Emerging Therapies Cancers, 2025
- Genome Editing Against HPV-Driven Cancers: From Bench to Clinic Acta Microbiologica Hellenica, 2025
- Exosomes in HPV-Associated Cancers: From Biomarkers to Engineered Therapeutics Cancers (Basel), 2025
- Molecular Insights into HPV-Driven Head and Neck Cancers: From Viral Oncoproteins to Precision Therapeutics Viruses, 2025
- Emerging Therapeutic Strategies for HPV-Related Cancers: From Gene Editing to Precision Oncology Current Issues in Molecular Biology, 2025
- Papillomavirus-Induced Oncogenesis: Bridging Molecular Mechanisms, Diagnostics, and Global Prevention Strategies Viruses, 2025
Genetics & Liquid Biopsy
Revolutionary studies mapping the cancer genome and diagnosing via blood samples.
- Analytical Validation of a 1021-Gene NGS Panel for Comprehensive Tumor Profiling in FFPE and Liquid Biopsy Samples Journal of Clinical Oncology, 2025
- Comprehensive Evaluation of a 1021-Gene Panel in FFPE and Liquid Biopsy for Analytical and Clinical Use International Journal of Molecular Sciences, 2025
- Multilocus inherited neoplasia allele syndrome (MINAS) in a Turkish cohort Frontiers in Pharmacology, 2025
- High-Throughput Drug Testing and Synergy Evaluation in Patient-Derived Tumor Organoids Methods in Molecular Biology, 2025
Therapeutic Resistance & Radiotherapy
Addressing the challenge of resistance mechanisms in solid tumors to improve treatment outcomes.
- Epigenetic Targeting of Radiotherapy Resistance in Solid Tumors: Mechanisms and Therapeutic Approaches Turkiye Klinikleri Radiation Oncology Special Issue, 2025 (National Publication)
Artificial Intelligence & Predictive Models
Computational oncology studies integrating future technologies into today's treatments.
- Predicting Drug Sensitivity of Cancer Cell Lines to BET Inhibitor OTX015 Using Machine Learning Approaches Preprints, 2025
- Predictive value of tumor marker index for pathological complete response in locally advanced rectal cancer World Journal of Surgical Oncology, 2025
Academic Leadership: Special Issue Editorships
To steer the direction of scientific communication and shape global discussions in oncology, we undertook "Guest Editor" roles in high-impact international journals. In 2025, we managed three major dossiers in both viral oncology and precision medicine.
A special issue addressing the role of the HPV family (over 100 types) in carcinogenesis, molecular mechanisms, diagnostic tools, and novel vaccine strategies on a global scale. This dossier enriched the literature with 12 comprehensive articles.
A comprehensive clinical dossier examining molecular foundations, biomarkers, and immunotherapy potentials of major infectious agents causing cancer, including not only HPV but also EBV, Hepatitis B/C, KSHV, HTLV-1, and H. pylori.
A research topic shaping the future of "personalized cancer treatment" by combining patient-derived organoids, multi-omics profiling, and liquid biopsy technologies to address tumor heterogeneity and drug resistance.
Published Books
Papillomavirus-Induced Oncogenesis: Current Insights
Publisher: MDPI, 2025
An international reference work covering molecular foundations and current treatment strategies of HPV-related cancers on a global scale.
The Book of Hereditary Cancers (Kalıtsal Kanserler Kitabı)
Scope: National
The first national reference work in Turkey addressing hereditary cancer syndromes with an interdisciplinary approach.
Innovation: From Theory to Practice
We are in the field with two ventures combining technology and medicine to transform academic knowledge into bedside benefits: CheckTheLife and CRISERNA.
Knowledge Multiplies as It Is Shared, Deepens as It Is Produced.
This list is not merely an inventory of a single year; it is a reflection of our determination in the fight against cancer. Knowing that every piece of knowledge we produced in 2025 across this broad spectrum—from laboratory to clinic, from editor's desk to entrepreneurial ecosystem—will one day touch a patient's life is our greatest motivation.
I would like to thank all my team members, assistants, and scientific partners who contributed to our work. We will continue working for more in 2026.